Arsenic Exposure in Utero Causes Obesity in Female Mice The August 2015 issue of Environmental Health Perspectives published an interesting article which showed that when female mice were exposed in utero to quite low levels of arsenic (in fact, the amount allowable to humans by EPA standards), they experiences early puberty and obesity. The male […]
Arsenic, Early Puberty, Endocrinology, Metabolism, Obesity, toxicology
Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice. Authors: Rodriguez KF, Ungewitter EK, Crespo-Mejias Y, Liu C, Nicol B, Kissling GE, Yao HH. Abstract BACKGROUND: Mice exposed to high levels of arsenic in utero are more susceptible to tumors such as hepatic and pulmonary carcinoma when they reach […]
Arsenic, Early Puberty, Endocrinology, Metabolism, Obesity, toxicologyBrain feminization requires active repression of masculinization via DNA methylation The March 30 issue of Nature Neuroscience includes an interesting article that may help explain different reproductive behaviors of male vs. females. Researchers at the University of Maryland studied development of fetal rats and found that the developing mammalian brain is destined for a female […]
Endocrinology, physiology, Preclinical Research, Sex DeterminantsBrain feminization requires active repression of masculinization via DNA methylation AUTHORS: Bridget M Nugent, Christopher L Wright, Amol C Shetty, Georgia E Hodes, Kathryn M Lenz, Anup Mahurkar, Scott J Russo, Scott E Devine & Margaret M McCarthy The developing mammalian brain is destined for a female phenotype unless exposed to gonadal hormones during a […]
Endocrinology, physiology, Preclinical Research, Sex Determinants